Cytochrome c1, heme protein, mitochondrial (CYC1)

About Cytochrome c1, heme protein, mitochondrial

Cytochrome c1, heme protein, mitochondrial (CYC1) is a protein from Homo sapiens identified by UniProt accession P08574, 325 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	Cytochrome c1, heme protein, mitochondrial
UniProt accession	P08574
Gene	CYC1
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (57)

Diseases linked to this target (Open Targets).

Isolated CoQ-cytochrome C reductase deficiency · score 0.77
neurodegenerative disease · score 0.54
neuroinflammatory disorder · score 0.19
mitochondrial disease · score 0.19
mean corpuscular hemoglobin concentration · score 0.18
mean corpuscular volume · score 0.12
mean corpuscular hemoglobin · score 0.11
blood metabolite measurement · score 0.09
eosinophil count · score 0.09
mean reticulocyte volume · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08574-F1	alphafold	PREDICTED	84.92	—

Amino-acid sequence (325 residues)

MAAAAASLRG VVLGPRGAGL PGARARGLLC SARPGQLPLR TPQAVALSSK SGLSRGRKVM LSALGMLAAG GAGLAMALHS AVSASDLELH PPSYPWSHRG LLSSLDHTSI RRGFQVYKQV CASCHSMDFV AYRHLVGVCY TEDEAKELAA EVEVQDGPNE DGEMFMRPGK LFDYFPKPYP NSEAARAANN GALPPDLSYI VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ AIAMAPPIYT DVLEFDDGTP ATMSQIAKDV CTFLRWASEP EHDHRKRMGL KMLMMMALLV PLVYTIKRHK WSVLKSRKLA YRPPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards