About Myosin light chain 3
Myosin light chain 3 (MYL3) is a protein
from Homo sapiens identified by UniProt accession
P08590, 195 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | Myosin light chain 3 |
|---|
| UniProt accession | P08590 |
|---|
| Gene | MYL3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 195 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (125)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy · score 0.80
- Rare familial disorder with hypertrophic cardiomyopathy · score 0.51
- familial hypertrophic cardiomyopathy · score 0.49
- cardiomyopathy · score 0.41
- Abnormality of the cardiovascular system · score 0.40
- cardiovascular disease · score 0.37
- heart failure · score 0.35
- urinary albumin to creatinine ratio · score 0.28
- Reduced left ventricular ejection fraction · score 0.28
- red blood cell density measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08590-F1 | alphafold | PREDICTED | 88.40 | — |
Amino-acid sequence (195 residues)
MAPKKPEPKK DDAKAAPKAA PAPAPPPEPE RPKEVEFDAS KIKIEFTPEQ IEEFKEAFML FDRTPKCEMK ITYGQCGDVL RALGQNPTQA EVLRVLGKPR QEELNTKMMD FETFLPMLQH ISKNKDTGTY EDFVEGLRVF DKEGNGTVMG AELRHVLATL GERLTEDEVE KLMAGQEDSN GCINYEAFVK HIMSS
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