About Tyrosine-protein kinase HCK
Tyrosine-protein kinase HCK (HCK) is a protein
from Homo sapiens identified by UniProt accession
P08631, 526 residues long.
MolForge cross-references it against 0 known binders and
366 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase HCK |
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| UniProt accession | P08631 |
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| Gene | HCK |
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| Organism | Homo sapiens |
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| Length | 526 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (366)
Diseases linked to this target (Open Targets).
- chronic myelogenous leukemia · score 0.60
- acute lymphoblastic leukemia · score 0.55
- neoplasm · score 0.48
- cutaneous Leishmaniasis · score 0.46
- lymphoid leukemia · score 0.45
- autoinflammation with pulmonary and cutaneous vasculitis · score 0.45
- neurodegenerative disease · score 0.42
- multiple myeloma · score 0.41
- HIV infection · score 0.39
- Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08631-F1 | alphafold | PREDICTED | 83.10 | — |
Amino-acid sequence (526 residues)
MGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT ETSASPHCPV YVPDPTSTIK PGPNSHNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ KGDQMVVLEE SGEWWKARSL ATRKEGYIPS NYVARVDSLE TEEWFFKGIS RKDAERQLLA PGNMLGSFMI RDSETTKGSY SLSVRDYDPR QGDTVKHYKI RTLDNGGFYI SPRSTFSTLQ ELVDHYKKGN DGLCQKLSVP CMSSKPQKPW EKDAWEIPRE SLKLEKKLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE AFLAEANVMK TLQHDKLVKL HAVVTKEPIY IITEFMAKGS LLDFLKSDEG SKQPLPKLID FSAQIAEGMA FIEQRNYIHR DLRAANILVS ASLVCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGSFTIKSDV WSFGILLMEI VTYGRIPYPG MSNPEVIRAL ERGYRMPRPE NCPEELYNIM MRCWKNRPEE RPTFEYIQSV LDDFYTATES QYQQQP
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