About Low affinity immunoglobulin gamma Fc region receptor III-A
Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A) is a protein
from Homo sapiens identified by UniProt accession
P08637, 254 residues long.
MolForge cross-references it against 0 known binders and
294 disease associations.
Target properties
| Protein name | Low affinity immunoglobulin gamma Fc region receptor III-A |
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| UniProt accession | P08637 |
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| Gene | FCGR3A |
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| Organism | Homo sapiens |
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| Length | 254 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (294)
Diseases linked to this target (Open Targets).
- autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity · score 0.71
- cutaneous Leishmaniasis · score 0.58
- leukocyte count · score 0.39
- blood protein measurement · score 0.39
- basophil count · score 0.33
- hemoglobin measurement · score 0.31
- hematocrit · score 0.31
- total blood protein measurement · score 0.30
- platelet component distribution width · score 0.27
- serum alanine aminotransferase measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08637-F1 | alphafold | PREDICTED | 85.68 | — |
Amino-acid sequence (254 residues)
MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN VSSETVNITI TQGLAVSTIS SFFPPGYQVS FCLVMVLLFA VDTGLYFSVK TNIRSSTRDW KDHKFKWRKD PQDK
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