Nuclear factor 1 C-type (NFIC)

About Nuclear factor 1 C-type

Nuclear factor 1 C-type (NFIC) is a protein from Homo sapiens identified by UniProt accession P08651, 508 residues long. MolForge cross-references it against 0 known binders and 365 disease associations.

Target properties

Protein name	Nuclear factor 1 C-type
UniProt accession	P08651
Gene	NFIC
Organism	Homo sapiens
Length	508 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (365)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.47
heel bone mineral density · score 0.46
body height · score 0.42
eosinophil count · score 0.37
platelet count · score 0.37
high density lipoprotein cholesterol measurement · score 0.37
neurodegenerative disease · score 0.36
bone quantitative ultrasound measurement · score 0.35
monocyte count · score 0.32
body weight · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08651-F1	alphafold	PREDICTED	60.88	—

Amino-acid sequence (508 residues)

MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL NPQDPLKDLV SLACDPASQQ PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP RLALPPATKP ATTSEGGATS PTSPSYSPPD TSPANRSFVG LGPRDPAGIY QAQSWYLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards