Vimentin (VIM)

About Vimentin

Vimentin (VIM) is a protein from Homo sapiens identified by UniProt accession P08670, 466 residues long. MolForge cross-references it against 0 known binders and 1,248 disease associations.

Target properties

Protein name	Vimentin
UniProt accession	P08670
Gene	VIM
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1248)

Diseases linked to this target (Open Targets).

Partial congenital cataract · score 0.46
Developmental cataract · score 0.43
pulverulent cataract · score 0.37
aspartate aminotransferase measurement · score 0.37
total cholesterol measurement · score 0.35
high density lipoprotein cholesterol measurement · score 0.32
low density lipoprotein cholesterol measurement · score 0.30
glioblastoma multiforme · score 0.29
hypertension · score 0.27
head and neck squamous cell carcinoma · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08670-F1	alphafold	PREDICTED	77.09	—

Amino-acid sequence (466 residues)

MSTRSVSSSS YRRMFGGPGT ASRPSSSRSY VTTSTRTYSL GSALRPSTSR SLYASSPGGV YATRSSAVRL RSSVPGVRLL QDSVDFSLAD AINTEFKNTR TNEKVELQEL NDRFANYIDK VRFLEQQNKI LLAELEQLKG QGKSRLGDLY EEEMRELRRQ VDQLTNDKAR VEVERDNLAE DIMRLREKLQ EEMLQREEAE NTLQSFRQDV DNASLARLDL ERKVESLQEE IAFLKKLHEE EIQELQAQIQ EQHVQIDVDV SKPDLTAALR DVRQQYESVA AKNLQEAEEW YKSKFADLSE AANRNNDALR QAKQESTEYR RQVQSLTCEV DALKGTNESL ERQMREMEEN FAVEAANYQD TIGRLQDEIQ NMKEEMARHL REYQDLLNVK MALDIEIATY RKLLEGEESR ISLPLPNFSS LNLRETNLDS LPLVDTHSKR TLLIKTVETR DGQVINETSQ HHDDLE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards