About Steroid 21-hydroxylase
Steroid 21-hydroxylase (CYP21A2) is a protein
from Homo sapiens identified by UniProt accession
P08686, 495 residues long.
MolForge cross-references it against 0 known binders and
185 disease associations.
Target properties
| Protein name | Steroid 21-hydroxylase |
|---|
| UniProt accession | P08686 |
|---|
| Gene | CYP21A2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 495 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (185)
Diseases linked to this target (Open Targets).
- classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency · score 0.83
- congenital adrenal hyperplasia · score 0.54
- genetic disorder · score 0.48
- classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form · score 0.37
- classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, salt wasting form · score 0.37
- adrenal gland disease · score 0.37
- blood protein measurement · score 0.34
- congenital lipoid adrenal hyperplasia due to STAR deficency · score 0.34
- complement C4 measurement · score 0.29
- allergic disease · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08686-F1 | alphafold | PREDICTED | 92.42 | — |
Amino-acid sequence (495 residues)
MLLLGLLLLL PLLAGARLLW NWWKLRSLHL PPLAPGFLHL LQPDLPIYLL GLTQKFGPIY RLHLGLQDVV VLNSKRTIEE AMVKKWADFA GRPEPLTYKL VSRNYPDLSL GDYSLLWKAH KKLTRSALLL GIRDSMEPVV EQLTQEFCER MRAQPGTPVA IEEEFSLLTC SIICYLTFGD KIKDDNLMPA YYKCIQEVLK TWSHWSIQIV DVIPFLRFFP NPGLRRLKQA IEKRDHIVEM QLRQHKESLV AGQWRDMMDY MLQGVAQPSM EEGSGQLLEG HVHMAAVDLL IGGTETTANT LSWAVVFLLH HPEIQQRLQE ELDHELGPGA SSSRVPYKDR ARLPLLNATI AEVLRLRPVV PLALPHRTTR PSSISGYDIP EGTVIIPNLQ GAHLDETVWE RPHEFWPDRF LEPGKNSRAL AFGCGARVCL GEPLARLELF VVLTRLLQAF TLLPSGDALP SLQPLPHCSV ILKMQPFQVR LQPRGMGAHS PGQSQ
Explore Steroid 21-hydroxylase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets