About Alpha-2-antiplasmin
Alpha-2-antiplasmin (SERPINF2) is a protein
from Homo sapiens identified by UniProt accession
P08697, 491 residues long.
MolForge cross-references it against 0 known binders and
254 disease associations.
Target properties
| Protein name | Alpha-2-antiplasmin |
|---|
| UniProt accession | P08697 |
|---|
| Gene | SERPINF2 |
|---|
| Organism | Homo sapiens |
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| Length | 491 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (254)
Diseases linked to this target (Open Targets).
- alpha-2-plasmin inhibitor deficiency · score 0.65
- Congenital alpha2 antiplasmin deficiency · score 0.50
- Rare hemorrhagic disorder due to a constitutional coagulation factors defect · score 0.45
- sex hormone-binding globulin measurement · score 0.39
- serum albumin measurement · score 0.38
- Abnormal bleeding · score 0.37
- testosterone measurement · score 0.34
- blood protein measurement · score 0.30
- calcium measurement · score 0.26
- adolescent idiopathic scoliosis · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08697-F1 | alphafold | PREDICTED | 78.09 | — |
Amino-acid sequence (491 residues)
MALLWGLLVL SWSCLQGPCS VFSPVSAMEP LGRQLTSGPN QEQVSPLTLL KLGNQEPGGQ TALKSPPGVC SRDPTPEQTH RLARAMMAFT ADLFSLVAQT STCPNLILSP LSVALALSHL ALGAQNHTLQ RLQQVLHAGS GPCLPHLLSR LCQDLGPGAF RLAARMYLQK GFPIKEDFLE QSEQLFGAKP VSLTGKQEDD LANINQWVKE ATEGKIQEFL SGLPEDTVLL LLNAIHFQGF WRNKFDPSLT QRDSFHLDEQ FTVPVEMMQA RTYPLRWFLL EQPEIQVAHF PFKNNMSFVV LVPTHFEWNV SQVLANLSWD TLHPPLVWER PTKVRLPKLY LKHQMDLVAT LSQLGLQELF QAPDLRGISE QSLVVSGVQH QSTLELSEVG VEAAAATSIA MSRMSLSSFS VNRPFLFFIF EDTTGLPLFV GSVRNPNPSA PRELKEQQDS PGNKDFLQSL KGFPRGDKLF GPDLKLVPPM EEDYPQFGSP K
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