Coagulation factor VII (F7)

About Coagulation factor VII

Coagulation factor VII (F7) is a protein from Homo sapiens identified by UniProt accession P08709, 466 residues long. MolForge cross-references it against 0 known binders and 426 disease associations.

Target properties

Protein name	Coagulation factor VII
UniProt accession	P08709
Gene	F7
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (426)

Diseases linked to this target (Open Targets).

congenital factor VII deficiency · score 0.81
factor VII deficiency · score 0.76
hemophilia A · score 0.55
hemophilia B · score 0.53
myocardial infarction · score 0.52
Abnormality of coagulation · score 0.44
factor VII measurement · score 0.41
Abnormal bleeding · score 0.39
blood protein measurement · score 0.39
Glanzmann thrombasthenia · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08709-F1	alphafold	PREDICTED	82.13	—

Amino-acid sequence (466 residues)

MVSQALRLLC LLLGLQGCLA AGGVAKASGG ETRDMPWKPG PHRVFVTQEE AHGVLHRRRR ANAFLEELRP GSLERECKEE QCSFEEAREI FKDAERTKLF WISYSDGDQC ASSPCQNGGS CKDQLQSYIC FCLPAFEGRN CETHKDDQLI CVNENGGCEQ YCSDHTGTKR SCRCHEGYSL LADGVSCTPT VEYPCGKIPI LEKRNASKPQ GRIVGGKVCP KGECPWQVLL LVNGAQLCGG TLINTIWVVS AAHCFDKIKN WRNLIAVLGE HDLSEHDGDE QSRRVAQVII PSTYVPGTTN HDIALLRLHQ PVVLTDHVVP LCLPERTFSE RTLAFVRFSL VSGWGQLLDR GATALELMVL NVPRLMTQDC LQQSRKVGDS PNITEYMFCA GYSDGSKDSC KGDSGGPHAT HYRGTWYLTG IVSWGQGCAT VGHFGVYTRV SQYIEWLQKL MRSEPRPGVL LRAPFP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards