Keratin, type I cytoskeletal 19 (KRT19)

About Keratin, type I cytoskeletal 19

Keratin, type I cytoskeletal 19 (KRT19) is a protein from Homo sapiens identified by UniProt accession P08727, 400 residues long. MolForge cross-references it against 0 known binders and 595 disease associations.

Target properties

Protein name	Keratin, type I cytoskeletal 19
UniProt accession	P08727
Gene	KRT19
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (595)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.19
glioblastoma multiforme · score 0.19
clear cell renal carcinoma · score 0.19
breast adenocarcinoma · score 0.18
esophageal cancer · score 0.14
hepatocellular carcinoma · score 0.13
hereditary breast ovarian cancer syndrome · score 0.12
Hereditary breast and ovarian cancer syndrome · score 0.12
neoplasm · score 0.12
papillary thyroid carcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08727-F1	alphafold	PREDICTED	79.91	—

Amino-acid sequence (400 residues)

MTSYSYRQSS ATSSFGGLGG GSVRFGPGVA FRAPSIHGGS GGRGVSVSSA RFVSSSSSGA YGGGYGGVLT ASDGLLAGNE KLTMQNLNDR LASYLDKVRA LEAANGELEV KIRDWYQKQG PGPSRDYSHY YTTIQDLRDK ILGATIENSR IVLQIDNARL AADDFRTKFE TEQALRMSVE ADINGLRRVL DELTLARTDL EMQIEGLKEE LAYLKKNHEE EISTLRGQVG GQVSVEVDSA PGTDLAKILS DMRSQYEVMA EQNRKDAEAW FTSRTEELNR EVAGHTEQLQ MSRSEVTDLR RTLQGLEIEL QSQLSMKAAL EDTLAETEAR FGAQLAHIQA LISGIEAQLG DVRADSERQN QEYQRLMDIK SRLEQEIATY RSLLEGQEDH YNNLSASKVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards