Keratin, type II cytoskeletal 7 (KRT7)

About Keratin, type II cytoskeletal 7

Keratin, type II cytoskeletal 7 (KRT7) is a protein from Homo sapiens identified by UniProt accession P08729, 469 residues long. MolForge cross-references it against 0 known binders and 618 disease associations.

Target properties

Protein name	Keratin, type II cytoskeletal 7
UniProt accession	P08729
Gene	KRT7
Organism	Homo sapiens
Length	469 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (618)

Diseases linked to this target (Open Targets).

prostate adenocarcinoma · score 0.19
clear cell renal carcinoma · score 0.19
head and neck squamous cell carcinoma · score 0.19
breast adenocarcinoma · score 0.18
neoplasm · score 0.12
colorectal carcinoma · score 0.10
cancer · score 0.10
pancreatic adenocarcinoma · score 0.09
inflammatory bowel disease · score 0.08
hepatocellular carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08729-F1	alphafold	PREDICTED	73.60	—

Amino-acid sequence (469 residues)

MSIHFSSPVF TSRSAAFSGR GAQVRLSSAR PGGLGSSSLY GLGASRPRVA VRSAYGGPVG AGIREVTINQ SLLAPLRLDA DPSLQRVRQE ESEQIKTLNN KFASFIDKVR FLEQQNKLLE TKWTLLQEQK SAKSSRLPDI FEAQIAGLRG QLEALQVDGG RLEAELRSMQ DVVEDFKNKY EDEINHRTAA ENEFVVLKKD VDAAYMSKVE LEAKVDALND EINFLRTLNE TELTELQSQI SDTSVVLSMD NSRSLDLDGI IAEVKAQYEE MAKCSRAEAE AWYQTKFETL QAQAGKHGDD LRNTRNEISE MNRAIQRLQA EIDNIKNQRA KLEAAIAEAE ERGELALKDA RAKQEELEAA LQRGKQDMAR QLREYQELMS VKLALDIEIA TYRKLLEGEE SRLAGDGVGA VNISVMNSTG GSSSGGGIGL TLGGTMGSNA LSFSSSAGPG LLKAYSIRTA SASRRSARD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards