About Guanine nucleotide-binding protein G(i) subunit alpha-3
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3) is a protein
from Homo sapiens identified by UniProt accession
P08754, 354 residues long.
MolForge cross-references it against 0 known binders and
164 disease associations.
Target properties
| Protein name | Guanine nucleotide-binding protein G(i) subunit alpha-3 |
|---|
| UniProt accession | P08754 |
|---|
| Gene | GNAI3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 354 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (164)
Diseases linked to this target (Open Targets).
- auriculocondylar syndrome · score 0.72
- Agnathia - holoprosencephaly - situs inversus · score 0.37
- breast adenocarcinoma · score 0.25
- lung adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.23
- body fat percentage · score 0.23
- endometrial cancer · score 0.23
- gastric adenocarcinoma · score 0.23
- genetic disorder · score 0.18
- chronotype measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08754-F1 | alphafold | PREDICTED | 93.82 | — |
Amino-acid sequence (354 residues)
MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLG AGESGKSTIV KQMKIIHEDG YSEDECKQYK VVVYSNTIQS IIAIIRAMGR LKIDFGEAAR ADDARQLFVL AGSAEEGVMT PELAGVIKRL WRDGGVQACF SRSREYQLND SASYYLNDLD RISQSNYIPT QQDVLRTRVK TTGIVETHFT FKDLYFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSDY DLVLAEDEEM NRMHESMKLF DSICNNKWFT ETSIILFLNK KDLFEEKIKR SPLTICYPEY TGSNTYEEAA AYIQCQFEDL NRRKDTKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKE CGLY
Explore Guanine nucleotide-binding protein G(i) subunit alpha-3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets