About Annexin A5
Annexin A5 (ANXA5) is a protein
from Homo sapiens identified by UniProt accession
P08758, 320 residues long.
MolForge cross-references it against 0 known binders and
644 disease associations.
Target properties
| Protein name | Annexin A5 |
|---|
| UniProt accession | P08758 |
|---|
| Gene | ANXA5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 320 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (644)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.46
- habitual abortion · score 0.40
- BMI-adjusted waist circumference · score 0.39
- waist-hip ratio · score 0.38
- breast adenocarcinoma · score 0.25
- sitting height measurement · score 0.18
- esophageal cancer · score 0.12
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.10
- oral squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08758-F1 | alphafold | PREDICTED | 96.13 | — |
Amino-acid sequence (320 residues)
MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR QEISAAFKTL FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL KGAGTNEKVL TEIIASRTPE ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ RMLVVLLQAN RDPDAGIDEA QVEQDAQALF QAGELKWGTD EEKFITIFGT RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV VKSIRSIPAY LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI KGDTSGDYKK ALLLLCGEDD
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