Keratin, type I cytoskeletal 16 (KRT16)

About Keratin, type I cytoskeletal 16

Keratin, type I cytoskeletal 16 (KRT16) is a protein from Homo sapiens identified by UniProt accession P08779, 473 residues long. MolForge cross-references it against 0 known binders and 173 disease associations.

Target properties

Protein name	Keratin, type I cytoskeletal 16
UniProt accession	P08779
Gene	KRT16
Organism	Homo sapiens
Length	473 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (173)

Diseases linked to this target (Open Targets).

pachyonychia congenita · score 0.71
Non-epidermolytic palmoplantar keratoderma · score 0.69
focal palmoplantar keratoderma · score 0.52
genetic disorder · score 0.19
glioblastoma multiforme · score 0.19
head and neck squamous cell carcinoma · score 0.19
prostate adenocarcinoma · score 0.18
clear cell renal carcinoma · score 0.18
breast adenocarcinoma · score 0.18
Localized epidermolytic hyperkeratosis · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08779-F1	alphafold	PREDICTED	71.54	—

Amino-acid sequence (473 residues)

MTTCSRQFTS SSSMKGSCGI GGGIGGGSSR ISSVLAGGSC RAPSTYGGGL SVSSRFSSGG ACGLGGGYGG GFSSSSSFGS GFGGGYGGGL GAGFGGGLGA GFGGGFAGGD GLLVGSEKVT MQNLNDRLAS YLDKVRALEE ANADLEVKIR DWYQRQRPSE IKDYSPYFKT IEDLRNKIIA ATIENAQPIL QIDNARLAAD DFRTKYEHEL ALRQTVEADV NGLRRVLDEL TLARTDLEMQ IEGLKEELAY LRKNHEEEML ALRGQTGGDV NVEMDAAPGV DLSRILNEMR DQYEQMAEKN RRDAETWFLS KTEELNKEVA SNSELVQSSR SEVTELRRVL QGLEIELQSQ LSMKASLENS LEETKGRYCM QLSQIQGLIG SVEEQLAQLR CEMEQQSQEY QILLDVKTRL EQEIATYRRL LEGEDAHLSS QQASGQSYSS REVFTSSSSS SSRQTRPILK EQSSSSFSQG QSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards