Insulin-like growth factor-binding protein 1 (IGFBP1)

About Insulin-like growth factor-binding protein 1

Insulin-like growth factor-binding protein 1 (IGFBP1) is a protein from Homo sapiens identified by UniProt accession P08833, 259 residues long. MolForge cross-references it against 0 known binders and 489 disease associations.

Target properties

Protein name	Insulin-like growth factor-binding protein 1
UniProt accession	P08833
Gene	IGFBP1
Organism	Homo sapiens
Length	259 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (489)

Diseases linked to this target (Open Targets).

body height · score 0.38
sex hormone-binding globulin measurement · score 0.24
cataract · score 0.24
urate measurement · score 0.24
vital capacity · score 0.23
puberty onset measurement · score 0.21
tonsillectomy risk measurement · score 0.19
cutaneous melanoma · score 0.18
head and neck squamous cell carcinoma · score 0.18
birth weight · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08833-F1	alphafold	PREDICTED	76.99	—

Amino-acid sequence (259 residues)

MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE VTRSAGCGCC PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG QGACVQESDA SAPHAAEAGS PESPESTEIT EEELLDNFHL MAPSEEDHSI LWDAISTYDG SKALHVTNIK KWKEPCRIEL YRVVESLAKA QETSGEEISK FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP GSPEIRGDPN CQIYFNVQN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards