Chymotrypsin-like elastase family member 3B (CELA3B)

About Chymotrypsin-like elastase family member 3B

Chymotrypsin-like elastase family member 3B (CELA3B) is a protein from Homo sapiens identified by UniProt accession P08861, 270 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Chymotrypsin-like elastase family member 3B
UniProt accession	P08861
Gene	CELA3B
Organism	Homo sapiens
Length	270 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

diabetes mellitus · score 0.37
pancreatic neoplasm · score 0.37
chronic pancreatitis · score 0.37
Malignant Pancreatic Neoplasm · score 0.37
neutrophil count · score 0.32
leukocyte count · score 0.31
myeloid white cell count · score 0.26
neutrophil percentage of leukocytes · score 0.25
monocyte percentage of leukocytes · score 0.24
atrial fibrillation · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08861-F1	alphafold	PREDICTED	90.78	—

Amino-acid sequence (270 residues)

MMLRLLSSLL LVAVASGYGP PSSRPSSRVV NGEDAVPYSW PWQVSLQYEK SGSFYHTCGG SLIAPDWVVT AGHCISSSRT YQVVLGEYDR AVKEGPEQVI PINSGDLFVH PLWNRSCVAC GNDIALIKLS RSAQLGDAVQ LASLPPAGDI LPNETPCYIT GWGRLYTNGP LPDKLQEALL PVVDYEHCSR WNWWGSSVKK TMVCAGGDIR SGCNGDSGGP LNCPTEDGGW QVHGVTSFVS AFGCNTRRKP TVFTRVSAFI DWIEETIASH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards