Small ribosomal subunit protein uS2 (RPSA)

About Small ribosomal subunit protein uS2

Small ribosomal subunit protein uS2 (RPSA) is a protein from Homo sapiens identified by UniProt accession P08865, 295 residues long. MolForge cross-references it against 0 known binders and 184 disease associations.

Target properties

Protein name	Small ribosomal subunit protein uS2
UniProt accession	P08865
Gene	RPSA
Organism	Homo sapiens
Length	295 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (184)

Diseases linked to this target (Open Targets).

familial isolated congenital asplenia · score 0.76
Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
COVID-19 · score 0.37
severe acute respiratory syndrome · score 0.37
Becker muscular dystrophy · score 0.30
qualitative or quantitative defects of dystrophin · score 0.26
schizophrenia · score 0.17
dentate gyrus volume measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08865-F1	alphafold	PREDICTED	79.22	—

Amino-acid sequence (295 residues)

MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR EVLRMRGTIS REHPWEVMPD LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA TQPEVADWSE GVQVPSVPIQ QFPTEDWSAQ PATEDWSAAP TAQATEWVGA TTDWS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards