Large ribosomal subunit protein uL3m (MRPL3)

About Large ribosomal subunit protein uL3m

Large ribosomal subunit protein uL3m (MRPL3) is a protein from Homo sapiens identified by UniProt accession P09001, 348 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	Large ribosomal subunit protein uL3m
UniProt accession	P09001
Gene	MRPL3
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

combined oxidative phosphorylation defect type 9 · score 0.72
neurodegenerative disease · score 0.46
mitochondrial disease · score 0.18
genetic disorder · score 0.12
alcohol consumption measurement · score 0.07
body mass index · score 0.07
wellbeing measurement · score 0.06
hemoglobin E-beta-thalassemia syndrome · score 0.06
Rh deficiency syndrome · score 0.06
gluthathione peroxidase deficiency · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P09001-F1	alphafold	PREDICTED	86.77	—

Amino-acid sequence (348 residues)

MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHPW EPGSFRVGLI ALKLGMMPLW TKDGQKHVVT LLQVQDCHVL KYTSKENCNG KMATLSVGGK TVSRFRKATS ILEFYRELGL PPKQTVKIFN ITDNAAIKPG TPLYAAHFRP GQYVDVTAKT IGKGFQGVMK RWGFKGQPAT HGQTKTHRRP GAVATGDIGR VWPGTKMPGK MGNIYRTEYG LKVWRINTKH NIIYVNGSVP GHKNCLVKVK DSKLPAYKDL GKNLPFPTYF PDGDEEELPE DLYDENVCQP GAPSITFA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards