About Homeobox protein Hox-D4
Homeobox protein Hox-D4 (HOXD4) is a protein
from Homo sapiens identified by UniProt accession
P09016, 255 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | Homeobox protein Hox-D4 |
|---|
| UniProt accession | P09016 |
|---|
| Gene | HOXD4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 255 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (83)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.31
- endometrial cancer · score 0.23
- pulse pressure measurement · score 0.23
- hair shape measurement · score 0.19
- diastolic blood pressure · score 0.18
- hypertension · score 0.17
- urate measurement · score 0.14
- ovarian carcinoma · score 0.11
- ovarian serous carcinoma · score 0.10
- facial morphology measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09016-F1 | alphafold | PREDICTED | 64.40 | — |
Amino-acid sequence (255 residues)
MVMSSYMVNS KYVDPKFPPC EEYLQGGYLG EQGADYYGGG AQGADFQPPG LYPRPDFGEQ PFGGSGPGPG SALPARGHGQ EPGGPGGHYA APGEPCPAPP APPPAPLPGA RAYSQSDPKQ PPSGTALKQP AVVYPWMKKV HVNSVNPNYT GGEPKRSRTA YTRQQVLELE KEFHFNRYLT RRRRIEIAHT LCLSERQIKI WFQNRRMKWK KDHKLPNTKG RSSSSSSSSS CSSSVAPSQH LQPMAKDHHT DLTTL
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