POU domain, class 2, transcription factor 2 (POU2F2)

About POU domain, class 2, transcription factor 2

POU domain, class 2, transcription factor 2 (POU2F2) is a protein from Homo sapiens identified by UniProt accession P09086, 479 residues long. MolForge cross-references it against 0 known binders and 180 disease associations.

Target properties

Protein name	POU domain, class 2, transcription factor 2
UniProt accession	P09086
Gene	POU2F2
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (180)

Diseases linked to this target (Open Targets).

diffuse large B-cell lymphoma · score 0.46
non-Hodgkins lymphoma · score 0.36
lymphoma · score 0.30
eosinophil count · score 0.23
chronotype measurement · score 0.15
forced expiratory volume · score 0.12
mean corpuscular hemoglobin concentration · score 0.11
sitting height measurement · score 0.11
alcohol consumption measurement · score 0.10
vital capacity · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P09086-F1	alphafold	PREDICTED	58.84	—

Amino-acid sequence (479 residues)

MVHSSMGAPE IRMSKPLEAE KQGLDSPSEH TDTERNGPDT NHQNPQNKTS PFSVSPTGPS TKIKAEDPSG DSAPAAPLPP QPAQPHLPQA QLMLTGSQLA GDIQQLLQLQ QLVLVPGHHL QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ TQGALLTSQP RAGLPTQAVT RPTLPDPHLS HPQPPKCLEP PSHPEEPSDL EELEQFARTF KQRRIKLGFT QGDVGLAMGK LYGNDFSQTT ISRFEALNLS FKNMCKLKPL LEKWLNDAET MSVDSSLPSP NQLSSPSLGF DGLPGRRRKK RTSIETNVRF ALEKSFLANQ KPTSEEILLI AEQLHMEKEV IRVWFCNRRQ KEKRINPCSA APMLPSPGKP ASYSPHMVTP QGGAGTLPLS QASSSLSTTV TTLSSAVGTL HPSRTAGGGG GGGGAAPPLN SIPSVTPPPP ATTNSTNPSP QGSHSAIGLS GLNPSTGPGL WWNPAPYQP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards