Chymotrypsin-like elastase family member 3A (CELA3A)

About Chymotrypsin-like elastase family member 3A

Chymotrypsin-like elastase family member 3A (CELA3A) is a protein from Homo sapiens identified by UniProt accession P09093, 270 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Chymotrypsin-like elastase family member 3A
UniProt accession	P09093
Gene	CELA3A
Organism	Homo sapiens
Length	270 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.40
alkaline phosphatase measurement · score 0.29
leukocyte count · score 0.27
monocyte percentage of leukocytes · score 0.26
granulocyte percentage of myeloid white cells · score 0.19
basophil count · score 0.17
neutrophil percentage of leukocytes · score 0.17
myeloid white cell count · score 0.16
bone quantitative ultrasound measurement · score 0.11
atrial flutter · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P09093-F1	alphafold	PREDICTED	90.68	—

Amino-acid sequence (270 residues)

MMLRLLSSLL LVAVASGYGP PSSHSSSRVV HGEDAVPYSW PWQVSLQYEK SGSFYHTCGG SLIAPDWVVT AGHCISRDLT YQVVLGEYNL AVKEGPEQVI PINSEELFVH PLWNRSCVAC GNDIALIKLS RSAQLGDAVQ LASLPPAGDI LPNKTPCYIT GWGRLYTNGP LPDKLQQARL PVVDYKHCSR WNWWGSTVKK TMVCAGGYIR SGCNGDSGGP LNCPTEDGGW QVHGVTSFVS AFGCNFIWKP TVFTRVSAFI DWIEETIASH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards