Gamma-enolase (ENO2)

About Gamma-enolase

Gamma-enolase (ENO2) is a protein from Homo sapiens identified by UniProt accession P09104, 434 residues long. MolForge cross-references it against 0 known binders and 899 disease associations.

Target properties

Protein name	Gamma-enolase
UniProt accession	P09104
Gene	ENO2
Organism	Homo sapiens
Length	434 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (899)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
mean corpuscular hemoglobin concentration · score 0.13
Hereditary breast and ovarian cancer syndrome · score 0.12
hereditary breast ovarian cancer syndrome · score 0.12
endometrial cancer · score 0.12
small cell lung carcinoma · score 0.12
neoplasm · score 0.10
gonorrhea · score 0.09
silicosis · score 0.09
neuroblastoma · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P09104-F1	alphafold	PREDICTED	97.08	—

Amino-acid sequence (434 residues)

MSIEKIWARE ILDSRGNPTV EVDLYTAKGL FRAAVPSGAS TGIYEALELR DGDKQRYLGK GVLKAVDHIN STIAPALISS GLSVVEQEKL DNLMLELDGT ENKSKFGANA ILGVSLAVCK AGAAERELPL YRHIAQLAGN SDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAESFRD AMRLGAEVYH TLKGVIKDKY GKDATNVGDE GGFAPNILEN SEALELVKEA IDKAGYTEKI VIGMDVAASE FYRDGKYDLD FKSPTDPSRY ITGDQLGALY QDFVRDYPVV SIEDPFDQDD WAAWSKFTAN VGIQIVGDDL TVTNPKRIER AVEEKACNCL LLKVNQIGSV TEAIQACKLA QENGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEELGDE ARFAGHNFRN PSVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards