3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)

About 3-ketoacyl-CoA thiolase, peroxisomal

3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) is a protein from Homo sapiens identified by UniProt accession P09110, 424 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	3-ketoacyl-CoA thiolase, peroxisomal
UniProt accession	P09110
Gene	ACAA1
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.33
mean reticulocyte volume · score 0.17
mean corpuscular hemoglobin concentration · score 0.08
neoplasm · score 0.07
non-small cell lung carcinoma · score 0.06
cancer · score 0.05
Red cell distribution width · score 0.05
lung adenocarcinoma · score 0.04
gut microbiome measurement · score 0.04
taxonomic microbiome measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P09110-F1	alphafold	PREDICTED	93.96	—

Amino-acid sequence (424 residues)

MQRLQVVLGH LRGPADSGWM PQAAPCLSGA PQASAADVVV VHGRRTAICR AGRGGFKDTT PDELLSAVMT AVLKDVNLRP EQLGDICVGN VLQPGAGAIM ARIAQFLSDI PETVPLSTVN RQCSSGLQAV ASIAGGIRNG SYDIGMACGV ESMSLADRGN PGNITSRLME KEKARDCLIP MGITSENVAE RFGISREKQD TFALASQQKA ARAQSKGCFQ AEIVPVTTTV HDDKGTKRSI TVTQDEGIRP STTMEGLAKL KPAFKKDGST TAGNSSQVSD GAAAILLARR SKAEELGLPI LGVLRSYAVV GVPPDIMGIG PAYAIPVALQ KAGLTVSDVD IFEINEAFAS QAAYCVEKLR LPPEKVNPLG GAVALGHPLG CTGARQVITL LNELKRRGKR AYGVVSMCIG TGMGAAAVFE YPGN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards