About Dopamine beta-hydroxylase
Dopamine beta-hydroxylase (DBH) is a protein
from Homo sapiens identified by UniProt accession
P09172, 617 residues long.
MolForge cross-references it against 0 known binders and
307 disease associations.
Target properties
| Protein name | Dopamine beta-hydroxylase |
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| UniProt accession | P09172 |
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| Gene | DBH |
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| Organism | Homo sapiens |
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| Length | 617 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (307)
Diseases linked to this target (Open Targets).
- orthostatic hypotension 1 · score 0.76
- systolic blood pressure · score 0.55
- diastolic blood pressure · score 0.54
- hypertension · score 0.50
- Calcium channel blocker use measurement · score 0.42
- genetic disorder · score 0.42
- smoking cessation · score 0.39
- cardiovascular disease · score 0.34
- blood pressure · score 0.33
- cigarettes per day measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09172-F1 | alphafold | PREDICTED | 90.04 | — |
Amino-acid sequence (617 residues)
MPALSRWASL PGPSMREAAF MYSTAVAIFL VILVAALQGS APRESPLPYH IPLDPEGSLE LSWNVSYTQE AIHFQLLVRR LKAGVLFGMS DRGELENADL VVLWTDGDTA YFADAWSDQK GQIHLDPQQD YQLLQVQRTP EGLTLLFKRP FGTCDPKDYL IEDGTVHLVY GILEEPFRSL EAINGSGLQM GLQRVQLLKP NIPEPELPSD ACTMEVQAPN IQIPSQETTY WCYIKELPKG FSRHHIIKYE PIVTKGNEAL VHHMEVFQCA PEMDSVPHFS GPCDSKMKPD RLNYCRHVLA AWALGAKAFY YPEEAGLAFG GPGSSRYLRL EVHYHNPLVI EGRNDSSGIR LYYTAKLRRF NAGIMELGLV YTPVMAIPPR ETAFILTGYC TDKCTQLALP PSGIHIFASQ LHTHLTGRKV VTVLVRDGRE WEIVNQDNHY SPHFQEIRML KKVVSVHPGD VLITSCTYNT EDRELATVGG FGILEEMCVN YVHYYPQTQL ELCKSAVDAG FLQKYFHLIN RFNNEDVCTC PQASVSQQFT SVPWNSFNRD VLKALYSFAP ISMHCNKSSA VRFQGEWNLQ PLPKVISTLE EPTPQCPTSQ GRSPAGPTVV SIGGGKG
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