Cystatin-SA (CST2)

About Cystatin-SA

Cystatin-SA (CST2) is a protein from Homo sapiens identified by UniProt accession P09228, 141 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	Cystatin-SA
UniProt accession	P09228
Gene	CST2
Organism	Homo sapiens
Length	141 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
cystatin-D measurement · score 0.27
protein measurement · score 0.20
gonorrhea · score 0.06
cyst · score 0.06
blood protein measurement · score 0.03
neoplasm · score 0.03
colorectal cancer · score 0.03
hepatocellular carcinoma · score 0.03
cystatin-SN measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P09228-F1	alphafold	PREDICTED	89.61	—

Amino-acid sequence (141 residues)

MAWPLCTLLL LLATQAVALA WSPQEEDRII EGGIYDADLN DERVQRALHF VISEYNKATE DEYYRRLLRV LRAREQIVGG VNYFFDIEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF QIYEVPWEDR MSLVNSRCQE A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards