About Matrilysin
Matrilysin (MMP7) is a protein
from Homo sapiens identified by UniProt accession
P09237, 267 residues long.
MolForge cross-references it against 0 known binders and
746 disease associations.
Target properties
| Protein name | Matrilysin |
|---|
| UniProt accession | P09237 |
|---|
| Gene | MMP7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 267 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (746)
Diseases linked to this target (Open Targets).
- acne · score 0.61
- periodontitis · score 0.60
- COVID-19 · score 0.60
- rosacea · score 0.60
- Helicobacter pylori infectious disease · score 0.59
- infection · score 0.59
- Lyme disease · score 0.57
- chronic obstructive pulmonary disease · score 0.57
- Borrelia infectious disease · score 0.56
- Chlamydia trachomatis infectious disease · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09237-F1 | alphafold | PREDICTED | 87.82 | — |
Amino-acid sequence (267 residues)
MRLTVLCAVC LLPGSLALPL PQEAGGMSEL QWEQAQDYLK RFYLYDSETK NANSLEAKLK EMQKFFGLPI TGMLNSRVIE IMQKPRCGVP DVAEYSLFPN SPKWTSKVVT YRIVSYTRDL PHITVDRLVS KALNMWGKEI PLHFRKVVWG TADIMIGFAR GAHGDSYPFD GPGNTLAHAF APGTGLGGDA HFDEDERWTD GSSLGINFLY AATHELGHSL GMGHSSDPNA VMYPTYGNGD PQNFKLSQDD IKGIQKLYGK RSNSRKK
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