About Fructose-1,6-bisphosphatase 1
Fructose-1,6-bisphosphatase 1 (FBP1) is a protein
from Homo sapiens identified by UniProt accession
P09467, 338 residues long.
MolForge cross-references it against 0 known binders and
229 disease associations.
Target properties
| Protein name | Fructose-1,6-bisphosphatase 1 |
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| UniProt accession | P09467 |
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| Gene | FBP1 |
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| Organism | Homo sapiens |
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| Length | 338 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (229)
Diseases linked to this target (Open Targets).
- fructose-1,6-bisphosphatase deficiency · score 0.81
- disorder of glycogen metabolism · score 0.50
- body height · score 0.42
- genetic disorder · score 0.41
- protein measurement · score 0.29
- type 2 diabetes mellitus · score 0.25
- cortical surface area measurement · score 0.25
- lean body mass · score 0.20
- colon carcinoma · score 0.13
- hepatocellular carcinoma · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09467-F1 | alphafold | PREDICTED | 94.32 | — |
Amino-acid sequence (338 residues)
MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ
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