Tropomyosin alpha-1 chain (TPM1)

About Tropomyosin alpha-1 chain

Tropomyosin alpha-1 chain (TPM1) is a protein from Homo sapiens identified by UniProt accession P09493, 284 residues long. MolForge cross-references it against 0 known binders and 253 disease associations.

Target properties

Protein name	Tropomyosin alpha-1 chain
UniProt accession	P09493
Gene	TPM1
Organism	Homo sapiens
Length	284 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (253)

Diseases linked to this target (Open Targets).

hypertrophic cardiomyopathy · score 0.82
left ventricular noncompaction · score 0.71
Rare familial disorder with hypertrophic cardiomyopathy · score 0.64
dilated cardiomyopathy · score 0.56
cardiomyopathy · score 0.54
Abnormality of the cardiovascular system · score 0.53
familial hypertrophic cardiomyopathy · score 0.49
mean platelet volume · score 0.42
platelet count · score 0.42
high density lipoprotein cholesterol measurement · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P09493-F1	alphafold	PREDICTED	91.63	—

Amino-acid sequence (284 residues)

MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards