About Clathrin light chain A
Clathrin light chain A (CLTA) is a protein
from Homo sapiens identified by UniProt accession
P09496, 248 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Clathrin light chain A |
|---|
| UniProt accession | P09496 |
|---|
| Gene | CLTA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 248 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (38)
Diseases linked to this target (Open Targets).
- influenza · score 0.37
- cutaneous melanoma · score 0.23
- esophageal cancer · score 0.13
- head and neck squamous cell carcinoma · score 0.11
- schizophrenia · score 0.11
- autism spectrum disorder · score 0.11
- PHF-tau measurement · score 0.11
- squamous cell lung carcinoma · score 0.11
- hepatocellular carcinoma · score 0.07
- protein measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09496-F1 | alphafold | PREDICTED | 70.11 | — |
Amino-acid sequence (248 residues)
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV DRLQSEPESI RKWREEQMER LEALDANSRK QEAEWKEKAI KELEEWYARQ DEQLQKTKAN NRVADEAFYK QPFADVIGYV TNINHPCYSL EQAAEEAFVN DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS LKQAPLVH
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