About 2',3'-cyclic-nucleotide 3'-phosphodiesterase
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) is a protein
from Homo sapiens identified by UniProt accession
P09543, 421 residues long.
MolForge cross-references it against 0 known binders and
281 disease associations.
Target properties
| Protein name | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
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| UniProt accession | P09543 |
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| Gene | CNP |
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| Organism | Homo sapiens |
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| Length | 421 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (281)
Diseases linked to this target (Open Targets).
- Myopia · score 0.50
- leukodystrophy, hypomyelinating, 20 · score 0.47
- blood protein measurement · score 0.12
- experimental autoimmune encephalomyelitis · score 0.06
- mean corpuscular hemoglobin · score 0.06
- reticulocyte count · score 0.06
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness · score 0.06
- spinocerebellar ataxia type 35 · score 0.06
- Autosomal dominant intermediate Charcot-Marie-Tooth disease type B · score 0.05
- Charcot-Marie-Tooth disease type 2B1 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09543-F1 | alphafold | PREDICTED | 87.27 | — |
Amino-acid sequence (421 residues)
MNRGFSRKSH TFLPKIFFRK MSSSGAKDKP ELQFPFLQDE DTVATLLECK TLFILRGLPG SGKSTLARVI VDKYRDGTKM VSADAYKITP GARGAFSEEY KRLDEDLAAY CRRRDIRILV LDDTNHERER LEQLFEMADQ YQYQVVLVEP KTAWRLDCAQ LKEKNQWQLS ADDLKKLKPG LEKDFLPLYF GWFLTKKSSE TLRKAGQVFL EELGNHKAFK KELRQFVPGD EPREKMDLVT YFGKRPPGVL HCTTKFCDYG KAPGAEEYAQ QDVLKKSYSK AFTLTISALF VTPKTTGARV ELSEQQLQLW PSDVDKLSPT DNLPRGSRAH ITLGCAADVE AVQTGLDLLE ILRQEKGGSR GEEVGELSRG KLYSLGNGRW MLTLAKNMEV RAIFTGYYGK GKPVPTQGSR KGGALQSCTI I
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