About Protein Wnt-2
Protein Wnt-2 (WNT2) is a protein
from Homo sapiens identified by UniProt accession
P09544, 360 residues long.
MolForge cross-references it against 0 known binders and
260 disease associations.
Target properties
| Protein name | Protein Wnt-2 |
|---|
| UniProt accession | P09544 |
|---|
| Gene | WNT2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 360 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (260)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- Parkinson disease · score 0.32
- lysosomal storage disease · score 0.32
- Alzheimer disease · score 0.32
- multiple sclerosis · score 0.32
- BMI-adjusted waist-hip ratio · score 0.27
- waist-hip ratio · score 0.26
- uterine fibroid · score 0.22
- tonsillectomy risk measurement · score 0.22
- Dupuytren Contracture · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09544-F1 | alphafold | PREDICTED | 88.79 | — |
Amino-acid sequence (360 residues)
MNAPLGGIWL WLPLLLTWLT PEVNSSWWYM RATGGSSRVM CDNVPGLVSS QRQLCHRHPD VMRAISQGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV LLRSSRESAF VYAISSAGVV FAITRACSQG EVKSCSCDPK KMGSAKDSKG IFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG TGFTVANERF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG MDSCEVMCCG RGYDTSHVTR MTKCGCKFHW CCAVRCQDCL EALDVHTCKA PKNADWTTAT
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