About Heme oxygenase 1
Heme oxygenase 1 (HMOX1) is a protein
from Homo sapiens identified by UniProt accession
P09601, 288 residues long.
MolForge cross-references it against 0 known binders and
1,213 disease associations.
Target properties
| Protein name | Heme oxygenase 1 |
|---|
| UniProt accession | P09601 |
|---|
| Gene | HMOX1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 288 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1213)
Diseases linked to this target (Open Targets).
- heme oxygenase 1 deficiency · score 0.68
- amyloidosis · score 0.46
- neurodegenerative disease · score 0.46
- cystic fibrosis · score 0.39
- blood protein measurement · score 0.28
- glioblastoma multiforme · score 0.21
- gastric adenocarcinoma · score 0.15
- PHF-tau measurement · score 0.14
- chronotype measurement · score 0.13
- neoplasm · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09601-F1 | alphafold | PREDICTED | 82.90 | — |
Amino-acid sequence (288 residues)
MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV ETPRGKPPLN TRSQAPLLRW VLTLSFLVAT VAVGLYAM
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