About Macrophage colony-stimulating factor 1
Macrophage colony-stimulating factor 1 (CSF1) is a protein
from Homo sapiens identified by UniProt accession
P09603, 554 residues long.
MolForge cross-references it against 0 known binders and
896 disease associations.
Target properties
| Protein name | Macrophage colony-stimulating factor 1 |
|---|
| UniProt accession | P09603 |
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| Gene | CSF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 554 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (896)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.46
- aspartate aminotransferase measurement · score 0.45
- lymphocyte count · score 0.44
- platelet count · score 0.44
- leukocyte count · score 0.44
- high density lipoprotein cholesterol measurement · score 0.43
- total blood protein measurement · score 0.42
- serum albumin measurement · score 0.40
- hemoglobin measurement · score 0.38
- platelet crit · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09603-F1 | alphafold | PREDICTED | 57.42 | — |
Amino-acid sequence (554 residues)
MTAPGAAGRC PPTTWLGSLL LLVCLLASRS ITEEVSEYCS HMIGSGHLQS LQRLIDSQME TSCQITFEFV DQEQLKDPVC YLKKAFLLVQ DIMEDTMRFR DNTPNAIAIV QLQELSLRLK SCFTKDYEEH DKACVRTFYE TPLQLLEKVK NVFNETKNLL DKDWNIFSKN CNNSFAECSS QDVVTKPDCN CLYPKAIPSS DPASVSPHQP LAPSMAPVAG LTWEDSEGTE GSSLLPGEQP LHTVDPGSAK QRPPRSTCQS FEPPETPVVK DSTIGGSPQP RPSVGAFNPG MEDILDSAMG TNWVPEEASG EASEIPVPQG TELSPSRPGG GSMQTEPARP SNFLSASSPL PASAKGQQPA DVTGTALPRV GPVRPTGQDW NHTPQKTDHP SALLRDPPEP GSPRISSLRP QGLSNPSTLS AQPQLSRSHS SGSVLPLGEL EGRRSTRDRR SPAEPEGGPA SEGAARPLPR FNSVPLTDTG HERQSEGSFS PQLQESVFHL LVPSVILVLL AVGGLLFYRW RRRSHQEPQR ADSPLEQPEG SPLTQDDRQV ELPV
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