About Dihydrolipoyl dehydrogenase, mitochondrial
Dihydrolipoyl dehydrogenase, mitochondrial (DLD) is a protein
from Homo sapiens identified by UniProt accession
P09622, 509 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Dihydrolipoyl dehydrogenase, mitochondrial |
|---|
| UniProt accession | P09622 |
|---|
| Gene | DLD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 509 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (117)
Diseases linked to this target (Open Targets).
- pyruvate dehydrogenase E3 deficiency · score 0.83
- Leigh syndrome · score 0.64
- maple syrup urine disease · score 0.57
- neurodegenerative disease · score 0.48
- genetic disorder · score 0.47
- maple syrup urine disease type 1A · score 0.46
- ulcerative colitis · score 0.42
- Alzheimer disease · score 0.39
- Parkinson disease · score 0.39
- inflammatory bowel disease · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09622-F1 | alphafold | PREDICTED | 93.98 | — |
Amino-acid sequence (509 residues)
MQSWSRVYCS LAKRGHFNRI SHGLQGLSAV PLRTYADQPI DADVTVIGSG PGGYVAAIKA AQLGFKTVCI EKNETLGGTC LNVGCIPSKA LLNNSHYYHM AHGKDFASRG IEMSEVRLNL DKMMEQKSTA VKALTGGIAH LFKQNKVVHV NGYGKITGKN QVTATKADGG TQVIDTKNIL IATGSEVTPF PGITIDEDTI VSSTGALSLK KVPEKMVVIG AGVIGVELGS VWQRLGADVT AVEFLGHVGG VGIDMEISKN FQRILQKQGF KFKLNTKVTG ATKKSDGKID VSIEAASGGK AEVITCDVLL VCIGRRPFTK NLGLEELGIE LDPRGRIPVN TRFQTKIPNI YAIGDVVAGP MLAHKAEDEG IICVEGMAGG AVHIDYNCVP SVIYTHPEVA WVGKSEEQLK EEGIEYKVGK FPFAANSRAK TNADTDGMVK ILGQKSTDRV LGAHILGPGA GEMVNEAALA LEYGASCEDI ARVCHAHPTL SEAFREANLA ASFGKSINF
Explore Dihydrolipoyl dehydrogenase, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets