Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)

About Heterogeneous nuclear ribonucleoprotein A1

Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) is a protein from Homo sapiens identified by UniProt accession P09651, 372 residues long. MolForge cross-references it against 0 known binders and 403 disease associations.

Target properties

Protein name	Heterogeneous nuclear ribonucleoprotein A1
UniProt accession	P09651
Gene	HNRNPA1
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (403)

Diseases linked to this target (Open Targets).

familial amyotrophic lateral sclerosis · score 0.61
inclusion body myopathy with Paget disease of bone and frontotemporal dementia · score 0.52
chronic progressive multiple sclerosis · score 0.51
amyotrophic lateral sclerosis · score 0.51
Finnish upper limb-onset distal myopathy · score 0.45
Amyotrophic lateral sclerosis · score 0.37
severe acute respiratory syndrome · score 0.37
relapsing-remitting multiple sclerosis · score 0.34
mean platelet volume · score 0.29
neurodegenerative disease · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P09651-F1	alphafold	PREDICTED	67.53	—

Amino-acid sequence (372 residues)

MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS GDGYNGFGND GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK PRNQGGYGGS SSSSSYGSGR RF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards