About Pro-cathepsin H
Pro-cathepsin H (CTSH) is a protein
from Homo sapiens identified by UniProt accession
P09668, 335 residues long.
MolForge cross-references it against 0 known binders and
162 disease associations.
Target properties
| Protein name | Pro-cathepsin H |
|---|
| UniProt accession | P09668 |
|---|
| Gene | CTSH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 335 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (162)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.47
- type 1 diabetes mellitus · score 0.47
- aspartate aminotransferase measurement · score 0.45
- multiple sclerosis · score 0.43
- Alzheimer disease · score 0.36
- lysosomal storage disease · score 0.36
- neurodegenerative disease · score 0.36
- Parkinson disease · score 0.36
- basal cell carcinoma · score 0.32
- type 2 diabetes mellitus · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09668-F1 | alphafold | PREDICTED | 93.89 | — |
Amino-acid sequence (335 residues)
MWATLPLLCA GAWLLGVPVC GAAELCVNSL EKFHFKSWMS KHRKTYSTEE YHHRLQTFAS NWRKINAHNN GNHTFKMALN QFSDMSFAEI KHKYLWSEPQ NCSATKSNYL RGTGPYPPSV DWRKKGNFVS PVKNQGACGS CWTFSTTGAL ESAIAIATGK MLSLAEQQLV DCAQDFNNHG CQGGLPSQAF EYILYNKGIM GEDTYPYQGK DGYCKFQPGK AIGFVKDVAN ITIYDEEAMV EAVALYNPVS FAFEVTQDFM MYRTGIYSST SCHKTPDKVN HAVLAVGYGE KNGIPYWIVK NSWGPQWGMN GYFLIERGKN MCGLAACASY PIPLV
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