About Tyrosine-protein kinase Fgr
Tyrosine-protein kinase Fgr (FGR) is a protein
from Homo sapiens identified by UniProt accession
P09769, 529 residues long.
MolForge cross-references it against 0 known binders and
333 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase Fgr |
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| UniProt accession | P09769 |
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| Gene | FGR |
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| Organism | Homo sapiens |
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| Length | 529 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (333)
Diseases linked to this target (Open Targets).
- chronic myelogenous leukemia · score 0.59
- acute lymphoblastic leukemia · score 0.55
- cutaneous Leishmaniasis · score 0.46
- lymphoid leukemia · score 0.45
- neoplasm · score 0.41
- multiple myeloma · score 0.40
- lymphoid neoplasm · score 0.37
- Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive · score 0.37
- leukemia · score 0.35
- acute myeloid leukemia · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09769-F1 | alphafold | PREDICTED | 82.18 | — |
Amino-acid sequence (529 residues)
MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL SSGKTGCIPS NYVAPVDSIQ AEEWYFGKIG RKDAERQLLS PGNPQGAFLI RESETTKGAY SLSIRDWDQT RGDHVKHYKI RKLDMGGYYI TTRVQFNSVQ ELVQHYMEVN DGLCNLLIAP CTIMKPQTLG LAKDAWEISR SSITLERRLG TGCFGDVWLG TWNGSTKVAV KTLKPGTMSP KAFLEEAQVM KLLRHDKLVQ LYAVVSEEPI YIVTEFMCHG SLLDFLKNPE GQDLRLPQLV DMAAQVAEGM AYMERMNYIH RDLRAANILV GERLACKIAD FGLARLIKDD EYNPCQGSKF PIKWTAPEAA LFGRFTIKSD VWSFGILLTE LITKGRIPYP GMNKREVLEQ VEQGYHMPCP PGCPASLYEA MEQTWRLDPE ERPTFEYLQS FLEDYFTSAE PQYQPGDQT
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