About Complement C1s subcomponent
Complement C1s subcomponent (C1S) is a protein
from Homo sapiens identified by UniProt accession
P09871, 688 residues long.
MolForge cross-references it against 0 known binders and
289 disease associations.
Target properties
| Protein name | Complement C1s subcomponent |
|---|
| UniProt accession | P09871 |
|---|
| Gene | C1S |
|---|
| Organism | Homo sapiens |
|---|
| Length | 688 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (289)
Diseases linked to this target (Open Targets).
- complement component C1s deficiency · score 0.66
- Ehlers-Danlos syndrome, periodontal type 2 · score 0.63
- hereditary angioedema · score 0.55
- Ehlers-Danlos syndrome, periodontitis type · score 0.52
- Systemic lupus erythematosus · score 0.48
- Anemia, Hemolytic, Autoimmune · score 0.46
- systemic lupus erythematosus · score 0.46
- immunodeficiency due to a classical component pathway complement deficiency · score 0.37
- immune system disease · score 0.37
- hemolysis · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09871-F1 | alphafold | PREDICTED | 87.90 | — |
Amino-acid sequence (688 residues)
MWCIVLFSLL AWVYAEPTMY GEILSPNYPQ AYPSEVEKSW DIEVPEGYGI HLYFTHLDIE LSENCAYDSV QIISGDTEEG RLCGQRSSNN PHSPIVEEFQ VPYNKLQVIF KSDFSNEERF TGFAAYYVAT DINECTDFVD VPCSHFCNNF IGGYFCSCPP EYFLHDDMKN CGVNCSGDVF TALIGEIASP NYPKPYPENS RCEYQIRLEK GFQVVVTLRR EDFDVEAADS AGNCLDSLVF VAGDRQFGPY CGHGFPGPLN IETKSNALDI IFQTDLTGQK KGWKLRYHGD PMPCPKEDTP NSVWEPAKAK YVFRDVVQIT CLDGFEVVEG RVGATSFYST CQSNGKWSNS KLKCQPVDCG IPESIENGKV EDPESTLFGS VIRYTCEEPY YYMENGGGGE YHCAGNGSWV NEVLGPELPK CVPVCGVPRE PFEEKQRIIG GSDADIKNFP WQVFFDNPWA GGALINEYWV LTAAHVVEGN REPTMYVGST SVQTSRLAKS KMLTPEHVFI HPGWKLLEVP EGRTNFDNDI ALVRLKDPVK MGPTVSPICL PGTSSDYNLM DGDLGLISGW GRTEKRDRAV RLKAARLPVA PLRKCKEVKV EKPTADAEAY VFTPNMICAG GEKGMDSCKG DSGGAFAVQD PNDKTKFYAA GLVSWGPQCG TYGLYTRVKN YVDWIMKTMQ ENSTPRED
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