Fructose-bisphosphate aldolase C (ALDOC)

About Fructose-bisphosphate aldolase C

Fructose-bisphosphate aldolase C (ALDOC) is a protein from Homo sapiens identified by UniProt accession P09972, 364 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.

Target properties

Protein name	Fructose-bisphosphate aldolase C
UniProt accession	P09972
Gene	ALDOC
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (112)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.10
glioblastoma multiforme · score 0.08
non-small cell lung carcinoma · score 0.08
breast cancer · score 0.08
melanoma · score 0.08
hypertriglyceridemia 2 · score 0.06
glioblastoma · score 0.06
cholesterol-ester transfer protein deficiency · score 0.06
hyperlipidemia due to hepatic triglyceride lipase deficiency · score 0.05
homozygous familial hypercholesterolemia · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P09972-F1	alphafold	PREDICTED	96.26	—

Amino-acid sequence (364 residues)

MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE NTEENRRLYR QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD KGIVVGIKVD KGVVPLAGTD GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKISERTPS ALAILENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC PIKYTPEEIA MATVTALRRT VPPAVPGVTF LSGGQSEEEA SFNLNAINRC PLPRPWALTF SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEVNGLAAQ GKYEGSGEDG GAAAQSLYIA NHAY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards