Ras-related protein Rab-40A-like (RAB40AL)

About Ras-related protein Rab-40A-like

Ras-related protein Rab-40A-like (RAB40AL) is a protein from Homo sapiens identified by UniProt accession P0C0E4, 278 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Ras-related protein Rab-40A-like
UniProt accession	P0C0E4
Gene	RAB40AL
Organism	Homo sapiens
Length	278 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

deafness-intellectual disability, Martin-Probst type syndrome · score 0.15
Blackfan-Diamond anemia · score 0.08
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
delta-beta-thalassemia · score 0.06
hemoglobin D disease · score 0.06
hemoglobin E-beta-thalassemia syndrome · score 0.06
Beta-thalassemia · score 0.05
Alpha-thalassemia · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0C0E4-F1	alphafold	PREDICTED	73.73	—

Amino-acid sequence (278 residues)

MSAPGSPDQA YDFLLKFLLV GDRDVGKSEI LESLQDGTAE SPYSHLGGID YKTTTILLDG QRVKLKLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFEGMDRWIK KIEEHAPGVP KILVGNRLHL AFKRQVPREQ AQAYAERLGV TFFEVSPLCN FNIIESFTEL ARIVLLRHRL NWLGRPSKVL SLQDLCCRTI VSCTPVHLVD KLPLPIALRS HLKSFSMAKG LNARMMRGLS YSLTTSSTHK RSSLCKVKIV CPPQSPPKNC TRNSCKIS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards