Histone H2A.Z (H2AZ1)

About Histone H2A.Z

Histone H2A.Z (H2AZ1) is a protein from Homo sapiens identified by UniProt accession P0C0S5, 128 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	Histone H2A.Z
UniProt accession	P0C0S5
Gene	H2AZ1
Organism	Homo sapiens
Length	128 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.27
Red cell distribution width · score 0.18
mean reticulocyte volume · score 0.18
reticulocyte measurement · score 0.17
platelet count · score 0.14
lean body mass · score 0.13
mean corpuscular volume · score 0.12
hepatocellular carcinoma · score 0.11
age at menopause · score 0.11
appendicular lean mass · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0C0S5-F1	alphafold	PREDICTED	90.38	—

Amino-acid sequence (128 residues)

MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG KKGQQKTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards