Histone H2A type 1 (H2AC11)

About Histone H2A type 1

Histone H2A type 1 (H2AC11) is a protein from Homo sapiens identified by UniProt accession P0C0S8, 130 residues long. MolForge cross-references it against 0 known binders and 125 disease associations.

Target properties

Protein name	Histone H2A type 1
UniProt accession	P0C0S8
Gene	H2AC11
Organism	Homo sapiens
Length	130 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (125)

Diseases linked to this target (Open Targets).

infectious disease · score 0.50
viral disease · score 0.50
multiple myeloma · score 0.26
schizophrenia · score 0.19
mean corpuscular volume · score 0.17
psoriasis · score 0.14
intelligence · score 0.12
serum albumin measurement · score 0.12
neuroticism measurement · score 0.11
eosinophil count · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0C0S8-F1	alphafold	PREDICTED	91.10	—

Amino-acid sequence (130 residues)

MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK TESHHKAKGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards