About Wee1-like protein kinase 2
Wee1-like protein kinase 2 (WEE2) is a protein
from Homo sapiens identified by UniProt accession
P0C1S8, 567 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Wee1-like protein kinase 2 |
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| UniProt accession | P0C1S8 |
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| Gene | WEE2 |
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| Organism | Homo sapiens |
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| Length | 567 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (26)
Diseases linked to this target (Open Targets).
- female infertility due to zona pellucida defect · score 0.51
- female infertility due to oocyte meiotic arrest · score 0.38
- sensory perception of bitter taste · score 0.12
- Female infertility due to fertilization defect · score 0.07
- premature ovarian failure 19 · score 0.05
- Rare genetic female infertility · score 0.05
- oocyte maturation defect 11 · score 0.05
- invasive hydatidiform mole · score 0.05
- oocyte/zygote/embryo maturation arrest 17 · score 0.05
- venous thromboembolism · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C1S8-F1 | alphafold | PREDICTED | 67.06 | — |
Amino-acid sequence (567 residues)
MDDKDIDKEL RQKLNFSYCE ETEIEGQKKV EESREASSQT PEKGEVQDSE AKGTPPWTPL SNVHELDTSS EKDKESPDQI LRTPVSHPLK CPETPAQPDS RSKLLPSDSP STPKTMLSRL VISPTGKLPS RGPKHLKLTP APLKDEMTSL ALVNINPFTP ESYKKLFLQS GGKRKIRGDL EEAGPEEGKG GLPAKRCVLR ETNMASRYEK EFLEVEKIGV GEFGTVYKCI KRLDGCVYAI KRSMKTFTEL SNENSALHEV YAHAVLGHHP HVVRYYSSWA EDDHMIIQNE YCNGGSLQAA ISENTKSGNH FEEPKLKDIL LQISLGLNYI HNSSMVHLDI KPSNIFICHK MQSESSGVIE EVENEADWFL SANVMYKIGD LGHATSINKP KVEEGDSRFL ANEILQEDYR HLPKADIFAL GLTIAVAAGA ESLPTNGAAW HHIRKGNFPD VPQELSESFS SLLKNMIQPD AEQRPSAAAL ARNTVLRPSL GKTEELQQQL NLEKFKTATL ERELREAQQA QSPQGYTHHG DTGVSGTHTG SRSTKRLVGG KSARSSSFTS GEREPLH
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