F-box/SPRY domain-containing protein 1 (FBXO45)

About F-box/SPRY domain-containing protein 1

F-box/SPRY domain-containing protein 1 (FBXO45) is a protein from Homo sapiens identified by UniProt accession P0C2W1, 286 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	F-box/SPRY domain-containing protein 1
UniProt accession	P0C2W1
Gene	FBXO45
Organism	Homo sapiens
Length	286 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

gut microbiome measurement · score 0.19
mean reticulocyte volume · score 0.19
mean corpuscular volume · score 0.17
velopharyngeal dysfunction · score 0.15
mouth mucosa disorder · score 0.10
lip disorder · score 0.10
hepatocellular carcinoma · score 0.08
non-small cell lung carcinoma · score 0.07
pachyonychia congenita · score 0.07
neoplasm · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0C2W1-F1	alphafold	PREDICTED	88.73	—

Amino-acid sequence (286 residues)

MAAPAPGAGA ASGGAGCSGG GAGAGAGSGS GAAGAGGRLP SRVLELVFSY LELSELRSCA LVCKHWYRCL HGDENSEVWR SLCARSLAEE ALRTDILCNL PSYKAKIRAF QHAFSTNDCS RNVYIKKNGF TLHRNPIAQS TDGARTKIGF SEGRHAWEVW WEGPLGTVAV IGIATKRAPM QCQGYVALLG SDDQSWGWNL VDNNLLHNGE VNGSFPQCNN APKYQIGERI RVILDMEDKT LAFERGYEFL GVAFRGLPKV CLYPAVSAVY GNTEVTLVYL GKPLDG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards