GATA-type zinc finger protein 1 (ZGLP1)

About GATA-type zinc finger protein 1

GATA-type zinc finger protein 1 (ZGLP1) is a protein from Homo sapiens identified by UniProt accession P0C6A0, 273 residues long. MolForge cross-references it against 0 known binders and 201 disease associations.

Target properties

Protein name	GATA-type zinc finger protein 1
UniProt accession	P0C6A0
Gene	ZGLP1
Organism	Homo sapiens
Length	273 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (201)

Diseases linked to this target (Open Targets).

inflammatory bowel disease · score 0.08
primary ovarian insufficiency · score 0.08
Crohn's disease · score 0.08
46,XX gonadal dysgenesis · score 0.08
azoospermia · score 0.08
ulcerative colitis · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
rheumatoid arthritis · score 0.06
partial chromosome Y deletion · score 0.06
Testicular regression syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0C6A0-F1	alphafold	PREDICTED	62.11	—

Amino-acid sequence (273 residues)

MEAEPIPDSS MPAKLLAPPC LNLERLGGSP SQEKPRTPGC CRISERSLWP ACQESVTALC FLQETVERLG QSPAQDTPVL GPCWDPMALG TQGRLLLDRD SKDTQTRISQ KGRRLQPPGT PSAPPQRRPR KQLNPCRGTE RVDPGFEGVT LKFQIKPDSS LQIIPTYSLP CSSRSQESPA DAVGGPAAHP GGTEAHSAGS EALEPRRCAS CRTQRTPLWR DAEDGTPLCN ACGIRYKKYG TRCSSCWLVP RKNVQPKRLC GRCGVSLDPI QEG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards