About Ankyrin repeat domain-containing protein 34C
Ankyrin repeat domain-containing protein 34C (ANKRD34C) is a protein
from Homo sapiens identified by UniProt accession
P0C6C1, 535 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 34C |
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| UniProt accession | P0C6C1 |
|---|
| Gene | ANKRD34C |
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| Organism | Homo sapiens |
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| Length | 535 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- neurofibrillary tangles measurement · score 0.26
- central corneal thickness · score 0.26
- refractive error measurement · score 0.09
- central nervous system cancer · score 0.04
- atypical teratoid rhabdoid tumor · score 0.04
- medulloblastoma · score 0.04
- astrocytoma · score 0.04
- glioblastoma multiforme · score 0.03
- testosterone measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C6C1-F1 | alphafold | PREDICTED | 54.67 | — |
Amino-acid sequence (535 residues)
MMDDDTELRT DGNSLLKAVW LGRLRLTRLL LEGGAYINES NDKGETALMV ACITKHVDQQ SISKSKMVKY LLDNRADPNI QDKSGKTALI HACIRRAGGE VVSLLLENGA DPSLEDRTGA SALVYAINAD DKDALKHLLD ACKAKGKEVI IITTDKSSSG TKTTKQYLNV PPSPKVEDRH SPPLCASPSD IELKALGLDS PLTEKEDDFF SLQAGHPSSC NTSKAVNEPG SPTRKVSNLK RARLPQLKRL QSEPWGLIAP SVLAASTRQD ETHGASTDNE VIKSISDISF PKRGPLSRTN SIDSKDPTLF HTVTEQVLKI PVSSAPASWK AAYEKGQAPH PRLARRGTLP VDQEKCGMGP SGPSALKEPA SLKWLENDLY DLDIQPGPDP PNSISLESGK GPLDRKKLNS SHLSLFHGSR ESLDTVPSTS PSSARRRPPH LLERRGSGTL LLDRISHTRP GFLPPLNVNL NPPIPDIRSS SKPSCSLASG LKSMVPVAPS SPKRVDLRSK KKLLRRHSMQ IEQMKQLSDF EEIMT
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