About Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LINGO3) is a protein
from Homo sapiens identified by UniProt accession
P0C6S8, 592 residues long.
MolForge cross-references it against 0 known binders and
9 disease associations.
Target properties
| Protein name | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 |
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| UniProt accession | P0C6S8 |
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| Gene | LINGO3 |
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| Organism | Homo sapiens |
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| Length | 592 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (9)
Diseases linked to this target (Open Targets).
- myoepithelial tumor · score 0.11
- Benign familial chorea · score 0.07
- Ataxia - oculomotor apraxia type 1 · score 0.05
- early-onset generalized limb-onset dystonia · score 0.05
- major depressive disorder · score 0.01
- colitis · score 0.01
- unipolar depression · score 0.00
- neoplasm · score 0.00
- metastatic melanoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C6S8-F1 | alphafold | PREDICTED | 85.89 | — |
Amino-acid sequence (592 residues)
MTCWLCVLSL PLLLLPAAPP PAGGCPARCE CTVQTRAVAC TRRRLTAVPD GIPAETRLLE LSRNRIRCLN PGDLAALPAL EELDLSENAI AHVEPGAFAN LPRLRVLRLR GNQLKLIPPG VFTRLDNLTL LDLSENKLVI LLDYTFQDLH SLRRLEVGDN DLVFVSRRAF AGLLALEELT LERCNLTALS GESLGHLRSL GALRLRHLAI ASLEDQNFRR LPGLLHLEID NWPLLEEVAA GSLRGLNLTS LSVTHTNITA VPAAALRHQA HLTCLNLSHN PISTVPRGSF RDLVRLRELH LAGALLAVVE PQAFLGLRQI RLLNLSNNLL STLEESTFHS VNTLETLRVD GNPLACDCRL LWIVQRRKTL NFDGRLPACA TPAEVRGDAL RNLPDSVLFE YFVCRKPKIR ERRLQRVTAT AGEDVRFLCR AEGEPAPTVA WVTPQHRPVT ATSAGRARVL PGGTLEIQDA RPQDSGTYTC VASNAGGNDT YFATLTVRPE PAANRTPGEA HNETLAALRA PLDLTTILVS TAMGCITFLG VVLFCFVLLF VWSRGRGQHK NNFSVEYSFR KVDGPAAAAG QGGARKFNMK MI
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