About C-type lectin domain family 2 member L
C-type lectin domain family 2 member L (CLEC2L) is a protein
from Homo sapiens identified by UniProt accession
P0C7M8, 214 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | C-type lectin domain family 2 member L |
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| UniProt accession | P0C7M8 |
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| Gene | CLEC2L |
|---|
| Organism | Homo sapiens |
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| Length | 214 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.21
- multiple sclerosis · score 0.21
- Parkinson disease · score 0.21
- Alzheimer disease · score 0.21
- lysosomal storage disease · score 0.21
- cortical surface area measurement · score 0.14
- grey matter volume measurement · score 0.09
- PHF-tau measurement · score 0.09
- central nervous system cancer · score 0.04
- glioblastoma multiforme · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C7M8-F1 | alphafold | PREDICTED | 82.19 | — |
Amino-acid sequence (214 residues)
MEPAREPPSR ARPPPPLAAR PAPAPAAPRP RSPAEAEARG PEGLLRRSGS GYEGSTSWKA ALEDTTTRLL LGAIAVLLFA ILVVMSILAS KGCIKCEAPC PEDWLLYGRK CYFFSEEPRD WNTGRQYCHT HEAVLAVIQS QKELEFMFKF TRREPWIGLR RVGDEFHWVN GDPFDPDTFT IAGPGECVFV EPTRLVSTEC LMTRPWVCSK MAYT
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