CDGSH iron-sulfur domain-containing protein 3…

About CDGSH iron-sulfur domain-containing protein 3, mitochondrial

CDGSH iron-sulfur domain-containing protein 3, mitochondrial (CISD3) is a protein from Homo sapiens identified by UniProt accession P0C7P0, 127 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	CDGSH iron-sulfur domain-containing protein 3, mitochondrial
UniProt accession	P0C7P0
Gene	CISD3
Organism	Homo sapiens
Length	127 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

genetic disorder · score 0.18
mean corpuscular hemoglobin concentration · score 0.16
turnpenny-fry syndrome · score 0.15
Wolfram syndrome · score 0.12
FEV/FVC ratio · score 0.11
appendicular lean mass · score 0.10
lean body mass · score 0.09
body height · score 0.09
heel bone mineral density · score 0.09
mean corpuscular hemoglobin · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0C7P0-F1	alphafold	PREDICTED	87.64	—

Amino-acid sequence (127 residues)

MRGAGAILRP AARGARDLNP RRDISSWLAQ WFPRTPARSV VALKTPIKVE LVAGKTYRWC VCGRSKKQPF CDGSHFFQRT GLSPLKFKAQ ETRMVALCTC KATQRPPYCD GTHRSERVQK AEVGSPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

CDGSH iron-sulfur domain-containing protein 3, mitochondrial (CISD3)