Age-related maculopathy susceptibility protein 2…

About Age-related maculopathy susceptibility protein 2

Age-related maculopathy susceptibility protein 2 (ARMS2) is a protein from Homo sapiens identified by UniProt accession P0C7Q2, 107 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Age-related maculopathy susceptibility protein 2
UniProt accession	P0C7Q2
Gene	ARMS2
Organism	Homo sapiens
Length	107 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

age-related macular degeneration · score 0.56
wet macular degeneration · score 0.42
atrophic macular degeneration · score 0.37
systolic blood pressure · score 0.34
cataract · score 0.34
FEV/FVC ratio · score 0.31
retinopathy · score 0.31
degeneration of macula and posterior pole · score 0.31
diabetic retinopathy · score 0.31
macular degeneration · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0C7Q2-F1	alphafold	PREDICTED	58.16	—

Amino-acid sequence (107 residues)

MLRLYPGPMV TEAEGKGGPE MASLSSSVVP VSFISTLRES VLDPGVGGEG ASDKQRSKLS LSHSMIPAAK IHTELCLPAF FSPAGTQRRF QQPQHHLTLS IIHTAAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Age-related maculopathy susceptibility protein 2 (ARMS2)